Associations of VDR polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients
10.16438/j.0513-4870.2017-0125
- VernacularTitle:VDR基因多态性与肾移植患者他克莫司浓度相关性的研究
- Author:
Li QIN
1
;
Jia-li LI
1
;
Xiao-man LIU
1
;
Xu-tao CHEN
2
;
Shu LIU
3
;
Long-shan LIU
2
;
Chang-xi WANG
2
;
Min HUANG
1
Author Information
1. Institute of Clinical Pharmacology, School of Pharmaceutical Sciences
2. Department of Kidney Transplant, the First Affiliated Hospital
3. Department of Pharmacy, Cancer Center, Sun Yat-sen University, Guangzhou 510080, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
tacrolimus;
VDR;
polymorphism;
renal transplantation
- From:
Acta Pharmaceutica Sinica
2017;52(5):760-765
- CountryChina
- Language:Chinese
-
Abstract:
The paper was aimed to investigate the association of VDR polymorphisms with tacrolimus (FK506) concentration in Chinese renal transplant recipients. A total of 114 renal transplant recipients receiving tacrolimus were genotyped for VDR rs1540339 and rs2853559 by Agena Bioscience MassARRAY® system and CYP3A5*3 by PCR-RFLP method. Trough concentrations of tacrolimus on day 7 after renal transplantation were collected from clinical data. Statistical analysis was performed with Spearman's correlation, Mann-Whitney U test and Kruskal-Wallis H test. The dose-adjusted concentration of tacrolimus in VDR rs2853559 GA and GG carriers were considerably higher than that of AA carriers. After stratification by CYP3A5*3 genotypes, VDR rs2853559 GA and GG carriers had a higher dose-adjusted tacrolimus concentration than that in AA carriers in CYP3A5 nonexpresser. CYP3A5*3 and VDR rs2853559 explained 45.6% variability of tacrolimus C0/D. In CYP3A5 non-expressers, VDR rs2853559 explained 14.4% variability of tacrolimus C0/D. The results illustrated that VDR rs2853559 polymorphisms was associated with tacrolimus concentrations, and the determination of this SNP may be useful for individualized medicine of tacrolimus.
