Natural modulators of transient receptor potential channels
10.16438/j.0513-4870.2016-1187
- VernacularTitle:靶向瞬时受体电位通道天然调节剂的研究进展
- Author:
Nan-kai CAO
1
;
Hai-ning LÜ
1
;
Ning-ning WEI
2
;
Jun LI
1
;
Peng-fei TU
1
;
Ke-wei WANG
2
;
Yong JIANG
1
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
2. School of Pharmacy, Qingdao University, Qingdao 266021, China
- Publication Type:REVIEWS
- Keywords:
transient receptor potential channel;
natural modulator;
TRPV;
TRPA;
TRPM;
TRPC;
capsaicin
- From:
Acta Pharmaceutica Sinica
2017;52(5):673-684
- CountryChina
- Language:Chinese
-
Abstract:
Transient receptor potential (TRP) channels are non-selective and cation-permeable channels in the cell membrane, widely distributed in tissues and organs of human body. As biosensors, TRP channels can regulate the functions of vision, hearing, taste, pain, and touch, etc. So far, more than 100 different kinds of natural modulators targeting TRP channels have been identified from 70 species of plants or animals. In this review article, we attempt to summarize the effect of known natural active compounds on TRP channels with focuses on their sources, structures, action features and mechanisms. Hopefully this review can provide some useful information that can facilitate discovery of more specific natural modulators, and development of innovative therapeutic drugs targeting TRP channels.
