Advance in the treatment of glioma by neural stem cells
10.16438/j.0513-4870.2016-1000
- VernacularTitle:神经干细胞治疗胶质瘤的研究进展
- Author:
Lin-ming LUO
1
;
Shi-feng CHU
1
;
Yi-na JIANG
1
;
Piao LUO
1
;
Nai-hong CHEN
1
Author Information
1. College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
- Publication Type:REVIEWS
- Keywords:
neural stem cell;
tumor tropism;
carrier;
glioma;
targeted therapy
- From:
Acta Pharmaceutica Sinica
2017;52(4):510-516
- CountryChina
- Language:Chinese
-
Abstract:
Neural stem cells (NSCs) posse the specialty of tumor tropism and be able to migrate specifically to tumor cells. NSCs are also cross the blood brain barrier. NSCs keep in touch with tumor cells preferentially under the tumor microenvironment, and surround the target cells. Based on these characteristics, NSCs can be used as a carrier for therapeutic virus, enzymes/prodrugs, genes or suicide genes, etc. which are selectively delivered to the glioma cells. NSCs may be modified by a variety of different genes to establish a reliable, safe and effective therapy for glioma.
