Application of magnetic iron oxide nanoparticles in magnetic resonance/photothermal dual-modal imaging
10.16438/j.0513-4870.2016-1118
- VernacularTitle:磁性四氧化三铁纳米粒在磁共振/光热双模式成像中的应用
- Author:
Dan-hua HUANG
1
;
Xue-yong QI
1
;
Yan-ru GE
1
;
Song SHEN
1
Author Information
1. College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang 212013, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
magnetic iron oxide nanoparticle;
magnetic resonance imaging;
photothermal imaging;
dual-modal imaging
- From:
Acta Pharmaceutica Sinica
2017;52(3):481-487
- CountryChina
- Language:Chinese
-
Abstract:
In this study, water-dispersible magnetic iron oxide (Fe3O4) nanoparticles were synthesized with solvothermal method. The nanoparticles were characterized with a transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The in vitro magnetic resonance response and photothermal conversion characteristics of the nanoparticles were evaluated. In addition, the cellular uptake, cytotoxicity and biodistribution were studied. Finally, magnetic resonance/photothermal dual-modal imaging effect of the as-synthesized Fe3O4 nanoparticles was investigated in the tumor-bearing mice. The results showed that the obtained magnetic nanoparticles were uniform with a mean diameter of about 125 nm. Moreover, the superparamagnetic Fe3O4 nanoparticles showed remarkable magnetic resonance response and photothermal conversion properties. The results of cellular experiments showed that the cell viability was nearly 85% even the concentration of the nanoparticles was up to 1 000 μg·mL-1, an indicator of good biocompatibility. In addition, the nanoparticles could be taken up by the tumor cells and then located in the cytoplasm. After intravenous injection, the nanoparticles were tended to enrich in the tumor over time, which is helpful in achieving dual-modal magnetic resonance/photothermal imaging. In sum, the obtained Fe3O4 nanoparticles showed great potential to be applied for multi-modal bio-imaging which may play an important role in the diagnosis of tumors.
