On-line detection of concentration process of Ganmaoling granules by near infrared spectroscopy combined with automatic control system
10.16438/j.0513-4870.2016-1030
- VernacularTitle:近红外光谱法结合自动化控制系统在感冒灵颗粒浓缩过程中的在线检测技术研究
- Author:
Xue-song LIU
1
;
Jia-shan CHEN
1
;
Guo-quan CHEN
1
;
Ping SHAO
2
;
Yong-jiang WU
1
Author Information
1. Institute of Modern Chinese Medicine, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China
2. NERC for the Pharmaceutical of Traditional Chinese Medicines, Benxi 117000, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
near infrared spectroscopy;
automatic control system;
Ganmaoling granule;
process analytical technology
- From:
Acta Pharmaceutica Sinica
2017;52(3):462-467
- CountryChina
- Language:Chinese
-
Abstract:
Our research was designed for on-line detection of multi-index in the concentration process of Ganmaoling granules by integration of near infrared spectroscopy and automatic control system. First, on-line detection system was set up in the concentration tank for Ganmaoling granules production. Spectra were scanned and values of chlorogenic acid, linarin, solid content and relative density were measured. Models of partial least squares regression were built and imported into near infrared workstation. By connecting the control system, real-time multi-index values were determined automatically in the concentration process. Results showed that correlation coefficients of chlorogenic acid, linarin, solid content and relative density models were 0.963, 0.989, 0.993 and 0.918, respectively. Relative standard errors of prediction were 3.71%, 4.28%, 4.17% and 0.24%, respectively, indicating a good performance and high accuracy of the models. Real-time data collection during the whole process was measured by the near infrared detecting system in the control system. In conclusion, the near infrared detection system is able to perform real-time automatic determination of multi-index in the concentration process of Ganmaoling granules with significant advantages.
