Effects of metoprolol or/and pravastatin on the pharmacokinetics of metformin in rats
10.16438/j.0513-4870.2016-0755
- VernacularTitle:美托洛尔或/和普伐他汀对大鼠二甲双胍药动学的影响
- Author:
Yan-rong MA
1
;
Yan-fang WU
1
;
Ying-qin DUAN
1
;
Guo-qiang ZHANG
1
;
Xin-an WU
1
Author Information
1. The First Hospital, Lanzhou University, Lanzhou 730000, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
metformin;
metoprolol;
pravastatin;
multiple drug interaction;
pharmacokinetics
- From:
Acta Pharmaceutica Sinica
2017;52(2):253-257
- CountryChina
- Language:Chinese
-
Abstract:
This study investigates the effects of metoprolol (METO) or/and pravastatin (PRAV) on the pharmacokinetics of metformin (METF) in rats. Twenty-eight male SD rats were divided into METF group, METF+METO group, METF+PRAV group and METF+METO+PRAV group. Blood samples were collected at 10, 20, 40, 60, 90, 120, 180, 240, 360, 480 and 600 min after oral administration of metformin, and concentration of metformin in plasma was determined by HPLC. Compared to the METF group, Cmax of metformin was significantly decreased (P<0.01) and MRT0-t, t1/2 and V were significantly increased in the METF+METO group; t1/2 was significantly decreased in the METF+PRAV group; Cmax was significantly decreased and MRT0-t was significantly increased in the METF+METO+PRAV group. Compared to the METF+METO group, MRT0-t of metformin was significantly decreased in the METF+METO+PRAV group. Compared to the METF+PRAV group, Cmax of metformin was significantly decreased (P<0.01), and MRT0-t, t1/2 and V were significantly increased in the METF+METO+PRAV group. There exist multiple drug interactions of metformin, metoprolol and pravastatin in rats.
