Mechanism study of prescription to treat Xiaoke based on the property and flavor theory of Chinese medicine and network pharmacology
10.16438/j.0513-4870.2016-0978
- VernacularTitle:基于中药性味理论和网络药理学方法的治疗消渴方药作用机制研究
- Author:
Jin TAO
1
;
Min JIANG
1
;
Lu-ying CHEN
1
;
Yuan-yuan HOU
1
;
De-qin ZHANG
2
;
Feng QIU
2
;
Gang BAI
1
Author Information
1. Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China
2. School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Xiaoke;
drug property;
network pharmacology;
glucolipid metabolism;
mechanism
- From:
Acta Pharmaceutica Sinica
2017;52(2):236-244
- CountryChina
- Language:Chinese
-
Abstract:
Property and flavor theory of traditional Chinese medicine (TCM) is the core base for clinical treatment of diseases. However, few research about its chemical and biological characterization was performed. In this paper, network pharmacology was adopted to review patterns around the theory of TCM. "Xiaoke" prescription database, which combinations of herb medicines for diabetes therapy, was firstly built to explore prescription regularity and screen core paired-components. The prescription regularity and molecular mechanism of flavor composition were explored through the relationship of "drug-compound-target-pathway-function" by ChEMBL, CTD and KEGG datebase. As a result, the tastes of "Gan" (sweetish taste) and "Ku" (bitter taste) were the popular therapeutic flavor to regulate the disorder of glucose and lipid metabolisms. The mechanism of Xiaoke was summarized from representative traditional Chinese medicine partner "Zhimu-Huangbai" and "Huangqi-Gegen". The key components of "Gan", including saponins stimulated insulin secretion, improve insulin resistance and promote glucose utilization. The components of "Ku", including flavonoids and alkaloids regulate inflammatory cytokines, promoted the utilization of glucose, improve endocrine and metabolism through MAPK, PI3K-Akt, PPAR signal pathway. The TCM therapeutic mechanism about "Xiaoke" was preliminarily summarized to clear "heat" by anti-inflammation and immunoregulation, to regulate glucolipid metabolism for removing the satiation of digestion, and to improve the utilization of insulin and diabetes complications for endocrine adjusting. The results demonstrate that therapeutic principle of TCM for "Xiaoke" is comprehensive via multi pathway. This study provides a new research method and strategy for exploring the mechanism of TCM for diabetes therapy.
