Prevention of abdominal adhesions in rats by rhynchophylline through inhibition of Smad singnaling pathway
10.16438/j.0513-4870.2016-0798
- VernacularTitle:钩藤碱通过抑制Smad信号通路磷酸化减轻腹腔粘连发生的作用机制
- Author:
Yu SONG
1
;
Hui ZHANG
1
;
Rui-li LIU
1
;
Guang-fan HAI
1
;
Tong WANG
1
;
Jia-xin YUE
1
;
Wei-li ZHANG
1
;
Yu-ke REN
1
Author Information
1. College of Pharmacy, Xinxiang Medical University, Xinxiang 453000, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
rhynchophylline;
abdominal adhesion;
transforming growth factor-β1;
connective tissue growth factor
- From:
Acta Pharmaceutica Sinica
2017;52(2):229-235
- CountryChina
- Language:Chinese
-
Abstract:
Postoperative intra-abdominal adhesion is one of the most common complications in the postoperative period. Current remedies are very ineffective to prevent the pathological outcomes except steroid hormones. Rhynchophylline is deemed as a pharmacologically active component from traditional Oriental medicine Uncaria rhynchophylla (Miq.) Jacks. (Rubiaceae). This study was designed to investigate the preventative effect of rhynchophylline on the abdominal adhesions in rats. Rhynchophylline relieved the experimental abdominal adhesion and decreased the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the blood serum in a dose-dependent manner. The levels of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) were reduced significantly in the peritoneal fluid. The potential mechanism of the activity is related to inhibition of the TGF-β1/Smad signaling pathway.
