Recent progress of reactive oxygen species-responsive drug delivery systems
10.16438/j.0513-4870.2016-0923
- VernacularTitle:活性氧自由基响应给药系统研究进展
- Author:
Guang-zhao LU
1
;
Cheng HOU
1
;
Yan-qiang ZHONG
1
;
Ying LU
1
;
Hao ZOU
1
Author Information
1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Publication Type:REVIEWS
- Keywords:
reactive oxygen species;
drug delivery system;
photosensitizer;
singlet oxygen
- From:
Acta Pharmaceutica Sinica
2017;52(2):206-213
- CountryChina
- Language:Chinese
-
Abstract:
Excessive reactive oxygen species (ROS) is associated with an array of pathological conditions, including cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases. However, ROS-responsive materials have drawn attention in the development of drug delivery systems. There are many types of ROS-responsive materials explored in drug delivery applications, including sulfur-based responsive polymers, selenium-based responsive polymers, tellurium-based responsive polymers, oxalate ester-containing polymers, phenylboronic ester-containing polymers and unsaturated lipids. When integrated with ROS-responsive drug delivery systems, a photosensitizer is used as a light-sensitive element to generate ROS, mainly singlet oxygen (1O2), which in turn activates the ROS-triggered drug delivery.
