Applications of immobilization techniques in the screening of active constituents from traditional Chinese medicines
10.16438/j.0513-4870.2016-0750
- VernacularTitle:固定化技术在中药活性成分筛选中的应用
- Author:
Yu-xiu YANG
1
;
Su-ying LI
2
;
Qian ZHANG
1
;
Zhi-ning XIA
1
;
Feng-qing YANG
1
Author Information
1. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400031, China
2. Department of Pharmacy, Henan Medical College, Zhengzhou 451191, China
- Publication Type:REVIEWS
- Keywords:
active ingredient;
screening;
biomaterial;
immobilized technique;
carrier material
- From:
Acta Pharmaceutica Sinica
2017;52(2):198-205
- CountryChina
- Language:Chinese
-
Abstract:
It has been an active approach to screen the active ingredients in traditional Chinese medicines (TCMs) according to the affinity property between small molecule compounds and biomaterials such as cells, bacteria and proteins. On the other hand, the biomaterials can be immobilized on a solid support before the screening procedure. The immobilization method not only can maintain the biological activities of biomaterials, but also have other advantages such as high efficiency, simple operation, easy to be continuous and automatic, etc. Carrier materials (solid supports) for the immobilization including silica gel, magnetic materials, hollow fiber, and the surface plasma resonance sensor chips have been used to immobilize biomaterials and successfully applied in the screening of active ingredients from TCMs. In this paper, applications of immobilization techniques in the screening of active components from TCMs were reviewed to provide a scientific reference to the future applications.
