Advances in studies of ileal apical sodium-dependent bile acid transporter
10.16438/j.0513-4870.2016-0654
- VernacularTitle:顶端Na+依赖性胆汁酸转运体相关研究进展
- Author:
Mao-xu GE
1
;
Ju-xian WANG
1
;
Rong-guang SHAO
1
;
Hong-wei HE
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
bile acid;
apical sodium-dependent bile acid transporter;
intestinal tract tumor;
hyperlipemia;
diabetes mellitus
- From:
Acta Pharmaceutica Sinica
2017;52(2):189-197
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal apical sodium-dependent bile acid transporter (ASBT) located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently, a number of investigations have been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal inflammation, tumorigenesis, diabetes mellitus and hyperlipemia, which suggests ASBT as a potential therapeutic target of these diseases. In this review, advances in the study of above-mentioned issues were summarized.
