Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors
10.16462/j.cnki.zhjbkz.2019.12.018
- Author:
Sui-ping HE
1
;
Jia-ping YE
;
Chan BAI
;
Ling-hua LI
;
Li-ya LI
;
Wei-ping CAI
;
Ying-ying WANG
;
Ying LI
;
Wen-cui ZHANG
;
Ning LIU
;
Zi-jun GONG
;
Zhen-jiang YAO
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
- Publication Type:Research Article
- Keywords:
HIV infectors;
Coagulase-negative staphylococci;
Methicillin-resistant coagulase -negative staphylococci;
Antibiotic resistance
- From:
Chinese Journal of Disease Control & Prevention
2019;23(12):1527-1530
- CountryChina
- Language:Chinese
-
Abstract:
Objective We aimed to elucidate the prevalence and the antibiotic resistance spectrum of nasal coagulase-negative staphylococci (CoNS) colonization among HIV infectors in Guangzhou. Method After isolation and identification, all CoNS isolates were tested for the antibiotic susceptibility, and the antibiotic resistance genes. Result Among the 1 001 HIV infectors, the prevalence of CoNS and MRCoNS were 57.44% and 48.15%, respectively. The three predominant resistant antibiotics of MRCoNS isolates were penicillin, erythromycin and trimethoprim-sulfame thoxazole, while predominant detection rates of genes were Aac(6’)-aph(2’)、ermC and linA genes. The multidrug resistance rate of MRCoNS isolates were significantly higher than methicillin-susceptible coagulase-negative staphylococci (MSCoNS) isolates (80.69% versus 39.66%, P<0.001, OR=6.36). Conclusions The prevalence and multidrug resistant rates of nasal colonization CoNS and MRCoNS are high among HIV infectors in Guangzhou. MRCoNS isolates were 6.36 times more likely to be of multidrug resistance than MSCoNS isolates.
