Distribution of HIV subtypes in HIV/AIDS patients in Guizhou from 2013 to 2017

Author: Xing-feng LIU ; Zhi-jian LI ; Xing FANG ; Xin-hui ZHANG ; Lu HUANG ; Huan WANG ; Zhi XIAO
Publication Type:Research Article
Keywords: AIDS; antiretroviral therapy; HIV; subtype distribution
From: Chinese Journal of Disease Control & Prevention 2019;23(12):1523-1526
CountryChina
Language:Chinese
Abstract: Objective To investigate the molecular characteristics of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients receiving antiretroviral therapy (ART) in Guizhou Province. Methods Using a convenience sampling strategy, 8 583 samples were collected in Guizhou and an investigation was conducted including face-to-face questionnaire interview and HIV testing. Results 1 511 cases failed in HIV suppression (viral load, VL>1 000 copies/ml). 1 410 cases (93.31%) were successfully genotyped with HIV pol gene, among which 51.42% were genotyped as CRF01_AE, 26.67% as CRF07_BC and 16.1% as CRF08_BC. Conclusion The subtype changes caused by HIV gene mutation should precede the changes of main transmission routes of HIV through the analysis in recent years. Timely monitoring the changes of HIV subtypes can be one of the main bases for the prevention and control of AIDS.