TNF-α rs1800629 polymorphisms in the genetic susceptibility to cervical cancer

Author: Bo DING ¹ ; Wei SUN ; Yang SHEN ; Yun-lang CAI ; Shi-zhi WANG
Author Information

1. Department of Obstetrics and Gynecoloty, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China
Publication Type:Research Article
Keywords: TNF-α; rs1800629; Polymorphism; Cervical cancer
From: Chinese Journal of Disease Control & Prevention 2019;23(7):850-855
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between tumor necrosis factor α (TNF-α) rs1800629 polymorphisms and cervical cancer risk. Methods A case-control study was carried out including 552 patients with cervical cancer and 654 normal controls during the same period. TNF-α rs1800629 polymorphisms were examined by Taqman-Probe assay method. The association between the genotypes and cervical cancer was analyzed by Logistic regression models. Stata 11.0 was used for the Meta-analysis. Results Compared with the TNF-α rs1800629 GG genotype, individuals with GA, AA and GA/AA genotypes showed no significant changes in the risk of cervical cancer (all P>0.05). Further Meta-analysis on the relationship between the polymorphisms of TNF-α rs1800629 and cervical cancer also suggested that there was no significant correlation between the genetic variation and the occurrence of cervical cancer. Conclusion The polymorphisms of TNF-α rs1800629 may not be related to cervical cancer risk in Chinese population.