Epidemiological characteristics and drug resistance surveillance of Shigella in infants and young children in Henan Province from 2013 to 2017
10.16462/j.cnki.zhjbkz.2019.07.018
- Author:
Yu-jiao MU
1
;
Ruo-lin WANG
;
Bai-fan ZHANG
;
Jia-yong ZHAO
;
Meng-lei LI
;
Sheng-li XIA
;
Xue-yong HUANG
Author Information
1. Institute for Communicable Disease Control and Prevention, Henan Provincial Center for Disease Prevention and Control, Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou 450016, China
- Publication Type:Research Article
- Keywords:
Infant;
Shigella;
Surveillance;
Serotyping;
Drug resistance;
Virulencegenes
- From:
Chinese Journal of Disease Control & Prevention
2019;23(7):835-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogenic characteristics of Shigella in infants from 2013 to 2017 in Henan Province. Methods From 2013 to 2017, 606 Shigella strains were isolated from 5 149 children with diarrhea under 5 years old in Henan Province. Serotyping, drug sensitivity test and Polymerase Chain Reaction detection of virulence gene methods were used to detect the pathogen of Shigella. Results The detection rate of Shigella in children with diarrhea was 11.77%, and the highest detection rate was in the 1-2 age group(24.08%). 606 Shigella strains were divided into two groups and 11 serotypes. Shigella flexneri accounted for 73.43%， and Shigella sonnei accounted for 26.57%. Resistance of 176 Shigella strains to ampicillin and naphthidine was serious (resistance rate > 90%), and the resistance rates to chloramphenicol, ciprofloxacin, norfloxacin and compound sulfamethoxamine were higher than 65%, and the sensitivity of imipenem and cephalosporin were higher. There were differences in drug resistance between Shigella flexneri and Shigella sonnei. The virulence genes of infants were mainly shET-1+, shET-2+, ipaH+ and ial+, and 5 avirulent strains were detected. Conclusions The bacterial dysentery of infants in Henan Province is dominated by Shigella flexneri. There are serious resistance and multidrug resistance to common antibiotics, and the dominant genes in different serotyping strains are different.
