The swelling behavior of choline fenofibrate hydrogel matrix tablets using dynamic image analysis
10.16438/j.0513-4870.2016-0501
- VernacularTitle:非诺贝酸胆碱盐凝胶骨架片溶胀行为的动态图像分析
- Author:
Zhen-yun LIU
1
;
Wan-zeng LIU
1
;
He-ran LI
1
;
Zhen LI
1
;
Han WANG
1
;
Fang-zheng LU
1
;
San-ming LI
1
Author Information
1. School of Pharmacy, Shenyang Pharmceutical University, Shenyang 110016, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
dynamic image analysis;
choline fenofibrate;
hydrogel matrix tablet;
hydroxypropyl methylcel-lulose;
volume swelling ratio;
strength of gel
- From:
Acta Pharmaceutica Sinica
2016;51(11):1770-
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study is to investigate the effects of formulation on the swelling behavior of choline fenofibrate hydrogel matrix tablets and reveal the relation between swelling property and release profile using dynamic image analysis. The volume swelling ratio (SR) and height/width (k) could evaluate the swelling behavior of matrix tablets well. The mount of hydroxypropyl methylcellulose (HPMC) and the ratio between K15M and K4M affected the volume swelling ratio, while PVP didn't. The three factors all impacted k, which was an indicator of the strength of the gel formed by HPMC. The accumulative release ratio and SR, the rate of swelling and the rate of release were compared. The proper model equations were established for the results with an excellent correlation. The results prove that there is a strong relevance between the swelling behavior and release property. This study provides a guideline in the study design for hydrogel matrix tablets.
