The determination and clinical application of inosine 5'-monophosphate dehydrogenase activity
10.16438/j.0513-4870.2016-0584
- VernacularTitle:次黄嘌呤单核苷酸脱氢酶的活性测定及临床应用
- Author:
Fei-yan LIU
1
;
Xiao-yan QIU
1
;
Zheng JIAO
1
Author Information
1. Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China
- Publication Type:REVIEWS
- Keywords:
inosine 5'-monophosphate dehydrogenase;
IMPDH inhibitor;
determination of IMPDH activity;
biomarker
- From:
Acta Pharmaceutica Sinica
2016;51(11):1666-
- CountryChina
- Language:Chinese
-
Abstract:
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in de novo biosynthesis of guanine and plays an important role in cell proliferation. In clinic, IMPDH inhibitors are mainly used in fields of anticancer, antiviral, anti-parasitic, and immunosuppressive chemotherapy. However, since there are usually great inter-and intra-individual variability between drug concentration and clinical effect of IMPDH inhibitors, the enzyme activity of IMPDH may be applied as a specific biomarker and combined with the pharmacokinetics (PK) monitoring to improve efficacy and safety of IMPDH inhibitors. This review aims to discuss the assay of IMPDH activity measurement and its clinical application in recent years and provide valuable insights and theoretical basis for the development of IMPDH inhibitors' pharmacodynamics monitoring.
