A new phenylacetamide from the seeds of <i>Lepidium apetalum</i> Willd

VernacularTitle:从北葶苈子中分离到的一个新苯乙酰胺类化合物
Author: Meng LI ¹ ; Xiao-ke ZHENG ² ; Zhi-guang ZHANG ² ; Jing-ke ZHANG ² ; Xuan ZHAO ² ; Yan-yun YANG ² ; Xiao-lan WANG ² ; Hai-xue KUANG ¹ ; Wei-sheng FENG ²
Author Information

1. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Publication Type:ORIGINAL ARTICLES
Keywords: Lepidium apetalum Willd; lepidiumamid A; chemical constituent; phenylacetamide; sulphur glycoside
From: Acta Pharmaceutica Sinica 2016;51(12):1881-
CountryChina
Language:Chinese
Abstract: The chemical constituents of the seeds of Lepidium apetalum Willd. were investigated using chromatographic methods, including Diaion HP-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, silica gel chromatography and semi-preparative-HPLC. Three compounds were isolated and their structures were elucidated by spectral data and physicochemical properties, which were identified as lepidiumamide A (1), cis-desulfoglucotropaeolin (2), trans-desulfoglucotropaeolin (3). Among those, compound 1 is a new phenylacetamide, compound 2 and 3 were isolated from this plant for the first time, and their configurations were also identified for the first time.