Recent advances in study of long β2-adrenoceptor agonist
10.16438/j.0513-4870.2016-0579
- VernacularTitle:长效β2受体激动剂的研究进展
- Author:
Xin-yue GE
1
;
Yong-mei MO
1
;
Li PAN
1
;
Mao-sheng CHENG
1
Author Information
1. Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, China
- Publication Type:REVIEWS
- Keywords:
long β2-adrenoceptor agonist;
asthma;
chronic obstructive pulmonary disease;
structure-activity relationship
- From:
Acta Pharmaceutica Sinica
2016;51(12):1838-
- CountryChina
- Language:Chinese
-
Abstract:
β2-Adrenoceptor agonists are highly effective bronchodilators and are widely used in the treatment of both chronic obstructive pulmonary disease (COPD) and asthma. In the last 15 years, there has been great interest within the pharmaceutical industry in the discovery of a long β2-adrenoceptor agonist for a mono-therapy or combination therapy. The search for new long-acting β2-adrenoreceptor agonists (LABA's), for the treatment of asthma and COPD, has become a very active area of drug discovery. This article reviews the mechanisms, potential candidates and research advances of long β2-adrenoceptor agonists.
