Research progress of antipsychotics
10.16438/j.0513-4870.2016-0449
- VernacularTitle:抗精神分裂症药物研究进展
- Author:
Fei-pu YANG
1
;
Yang HE
1
;
Zhen WANG
1
;
Yu WANG
1
;
Xiang-rui JIANG
1
;
Jing-shan SHEN
1
Author Information
1. CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
- Publication Type:REVIEWS
- Keywords:
antipsychotics;
D2/5-HTHT2 receptor;
positive symptom;
negative symptom;
cognitive deficit
- From:
Acta Pharmaceutica Sinica
2016;51(12):1809-
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiology indicates that schizophrenia affects approximately 8‰ of the world's population. The atypical (second and third generation) antipsychotics generally endowed with D2/5-HTHT2 receptors antagonism properties are commonly used as first-line drugs for the treatment of schizophrenia presently. They have been proven effective in the treatment of positive and negative symptoms of schizophrenia, but they are largely ineffective in the treatment of cognitive deficit. Moreover, the atypical antipsychotics are usually associated with cardiovascular and metabolic side effects such as QT prolongation and weight gain. To develop more potent antipsychotics with fewer side effects, more targets have been identified such as D3, glutamate, H3 receptors and PDE10A in recent years. Herein, the research progress of antipsychotics is reviewed.
