Serum CRP level is positively correlated with the cardiovascular disease in dialysis patients.
- Author:
Kyun Sang LEE
1
;
Youn Kyoung LEE
;
Byoung Seok PARK
;
Taek Kyun JEONG
;
Gyun Ho JEONG
;
Seong Kwon MA
;
Soo Wan KIM
;
Nam Ho KIM
;
Ki Chul CHOI
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. Choikc@chonnam.chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
C-reactive protein;
Dialysis;
Inflammation;
Cardiovascular Diseases;
Atherosclerosis
- MeSH:
Atherosclerosis;
Body Mass Index;
C-Reactive Protein;
Cardiovascular Diseases*;
Creatinine;
Dialysis*;
Ferritins;
Humans;
Inflammation;
Logistic Models;
Male;
Mortality;
Peritoneal Dialysis;
Renal Dialysis;
Retrospective Studies;
Serum Albumin;
Smoke;
Smoking
- From:Korean Journal of Medicine
2002;63(6):668-674
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Atherosclerosis, a major problem in patients undergoing chronic dialysis treatment, has been characterized as an inflammatory disease. Cardiovascular disease is the major cause of mortality, accouting for approximately half of all deaths in this population. The present study was aimed whether CRP, an important inflammatory marker, might be associated with cardiovascular risk in dialysis patients. METHODS: We performed retrospective study in 77 dialysis patients. Patients were divided into the elevated CRP group (>8 mg/L, n=11) and the normal CRP group (8 mg/L) showed significant higher cardiovascular events (by chi-squre test, p=0.032). BMI, smoking, alcohol, dialysis modality, lipid parameters, BUN, serum creatinine, serum protein, serum albumin and seurm TIBC did not show significant difference between two groups. Correlation between CRP and other biochemical parameters was analysed. Only ESR was positively correlated with CRP. In a subsequent analysis, elevated CRP group had significantly higher cardiovascular risk (by stepwise logistic regression method, odd ratio = 6.59;95% CI, 1.13 to 38.28). CONCLUSION: These results suggest that CRP level is correlated with cardiovascular risk in dialysis patients.
