Using the cumulative odds Logit model to explore the application of the questionnaire derived from PANSS
10.16438/j.0513-4870.2016-0259
- VernacularTitle:应用累积比数Logit模型对PANSS评分表衍生调查问卷的初步分析
- Author:
Shuang-min JI
1
;
An-ning LI
2
;
Fang DONG
2
;
Liang LI
1
;
Tian-yan ZHOU
1
;
Chuan-yue WANG
2
;
Wei LU
1
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
2. Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
cumulative odds Logit model;
positive and negative syndrome scale;
schizophrenia;
clinical application
- From:
Acta Pharmaceutica Sinica
2016;51(10):1572-
- CountryChina
- Language:Chinese
-
Abstract:
Currently, aripiprazole, olanzapine and risperidone are three anti-psychiatry agents commonly used in the treatment of schizophrenia. Although the efficacy of these drugs is good, schizophrenia cannot be completely cured yet. Patients need long-term medication. The family members of patients may play a key role to understand the disease status of patients after patient discharge from hospital. PANSS is a commonly used scale in the clinic to evaluate the disease status and drug effects of anti-psychiatry agents. It was professionally written, and is not user friendly to amateurs. In the previous study, we developed a questionnaire for patient's family members to monitor the disease status. In this study, we explored the correlations between the results of questionnaire and 5 kinds of disease state corresponding to different PANSS score interval using the cumulative odds Logit model. The final results show that the model had relatively good prediction ability for aripiprazole, olanzapine and risperidone, suggesting that the questionnaire has an extensive prospect of clinical applications.
