Advances in study of macrophages in chemotherapy resistance of cancer
10.16438/j.0513-4870.2016-0393
- VernacularTitle:巨噬细胞参与调控肿瘤化疗耐药性的研究进展
- Author:
Hui-hui CHEN
1
;
Gui-kai LIANG
1
;
Zhang-ting YAO
1
;
Jie-qiong ZHANG
1
;
Xi CHEN
1
;
Ling DING
1
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
- Publication Type:REVIEWS
- Keywords:
malignant tumor;
macrophage;
chemotherapy resistance
- From:
Acta Pharmaceutica Sinica
2016;51(10):1513-
- CountryChina
- Language:Chinese
-
Abstract:
As extremely important inflammatory cells in the tumor microenvironment, tumor-associated macrophages (TAMs) can secrete a variety of chemokines and cytokines, which play an important role in the occurrence of tumor growth and metastasis. Recent years, increasing studies have shown that macrophages are associated with tumor chemotherapy sensitivity. The chemical substances produced by macrophages affect the efficacy of chemotherapeutic agents. In addition, some chemotherapeutic agents have an effect on the recruitment and bioactivity of macrophages in the tumor issue, which influences the anti-tumor efficacy of chemotherapy drugs. In this review, we summarize the roles of macrophages in the chemotherapy resistance, including the regulatory mechanism and the strategy of targeting macrophages.
