Irinotecan (CPT-11)-induced hemorrhagic colitis.
- Author:
Jung Han KIM
1
;
Min Ho CHOI
;
Je Hyun RYU
;
Hyun Joo JANG
;
Chang Soo EUN
;
Sea Hyub KAE
;
Jin LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea. jinleeprof@hanmail.net
- Publication Type:Case Report
- Keywords:
Irinotecan;
Colitis
- MeSH:
Colitis*;
Colonic Neoplasms;
Colorectal Neoplasms;
Diarrhea;
DNA Topoisomerases, Type I;
Humans;
Intestinal Perforation;
Ulcer
- From:Korean Journal of Medicine
2002;63(6):688-691
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Irinotecan (CPT-11) is a chemotherapeutic agent that inhibits topoisomerase I and has shown efficacy against advanced colorectal cancer. Diarrhea is the most common toxicity that has been reported to be as high as 87% in patients treated with irinotecan. However, the serious complications including acute hemorrhagic colitis, intestinal ulceration, and intestinal perforation may be uncommon events with irinotecan therapy. We report the first Korean case of acute hemorrhagic colitis induced by irinotecan administration in the patient with advanced colon cancer.
