Chemical constituents of Lonicera japonica roots and their anti-inflammatory effects
10.16438/j.0513-4870.2016-0208
- VernacularTitle:忍冬根的化学成分及其抗炎作用
- Author:
Jin-qian YU
1
;
Zhao-ping WANG
2
;
Heng ZHU
2
;
Gang LI
2
;
Xiao WANG
1
Author Information
1. Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Jinan 250014, China
2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
roots of Lonicera japonica;
chemical constituent;
identification;
zebrafish;
anti-inflammatory
- From:
Acta Pharmaceutica Sinica
2016;51(7):1110-
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical composition and their anti-inflammatory activities of honeysuckle (Lonicera japonica Thunb.) roots, seventeen compounds were isolated from the roots of L. japonica Thunb. by various chromatography, including silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified by MS, IR, and nuclear magnetic resonance spectra, as 1-oxo-(1H)-cyclopenta[b]benzofuran-7-carbaldehyde (1), 4-hydroxycinnamic acid (2), chlorogenic acid (3), loganin aglycone (4), caffeic acid (5), secologanin dimethyl acetal (6), korolkoside (7), coniferin (8), sweroside (9), secoxyloganin (10), 5-O-caffeoylquinic acid (11), chlorogenic acid methyl ester (12), chlorogenic acid ethyl ester (13), 3, 5-O-dicaffeoylquinic acid (14), 4, 5-O-dicaffeoylquinic acid (15), grandifloroside (16), and 4, 5-O-dicaffeoylquinic acid (17). Among those, compound 1 is a new compound, and compound 8 is found in L. japonica for the first time. Compounds 1, 3, 14-17 showed significant anti-inflammatory activities against macrophage in zebrafish.
