Advances in the studies of the link between diabetes and cancer
10.16438/j.0513-4870.2016-0254
- VernacularTitle:糖尿病促进肿瘤发生发展的研究进展
- Author:
Jiao-jiao YU
1
;
Fang HUA
1
;
Zhuo-wei HU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
diabetes;
cancer;
insulin;
obesity;
diabetes medication
- From:
Acta Pharmaceutica Sinica
2016;51(7):1017-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes and cancer are two major chronic diseases with tremendous impact on human health worldwide. Clinical and basic studies demonstrate that diabetes can promote carcinogenesis and tumor progression. High insulin and high insulin-like growth factor are considered to be the major risk factors for cancer. Chronic inflammation and aberrant metabolism also participate in cancer development. It is noteworthy that therapies used for treatment of diabetes may increase or decrease the risk of cancer. Revealing the mechanisms that connect diabetes to cancer will be crucial for prevention and treatment of diabetes-related cancers.
