Sulfur-containing derivatives as characteristic chemical markers in control of sulfur-fumigated Moutan Cortex
10.16438/j.0513-4870.2015-1120
- VernacularTitle:特征含硫衍生物对硫熏牡丹皮检控的意义
- Author:
Xiu-yang LI
1
;
Su-min DUAN
2
;
Huan-huan LIU
1
;
Jin-di XU
1
;
Ming KONG
1
;
Hong-quan LIU
3
;
Song-lin LI
1
Author Information
1. Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nangjing 210028, China
2. Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, Nangjing 210028, China
3. Department of Neurology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nangjing 210028, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Moutan Cortex;
sulfur-fumigation;
sulfur dioxide residue;
sulfur-containing derivative;
UPLCQTOF- MS/MS
- From:
Acta Pharmaceutica Sinica
2016;51(6):972-
- CountryChina
- Language:Chinese
-
Abstract:
The amount of sulfur dioxide residue is currently employed by Chinese Pharmacopoeia (CP) as an index to screen sulfur-fumigated herbs, but it is unclear if this index can objectively reflect the quality of sulfur-fumigated herbs. In the present study, sulfur-containing derivatives were confirmed in sulfur-fumigated Moutan Cortex (MC) by UPLC-QTOF-MS/MS analysis, and the contents of sulfur-containing derivatives and sulfur dioxide residues were statistically analyzed both in self-made and commercially available sulfur-fumigated and non-fumigated MC as well as the samples thereof before and after eight-month storage. The amount of sulfur dioxide was significantly decreased, but that of the newly-generated sulfur-containing markers was not, after eight-month storage of the sulfur-fumigated MC samples, indicating that the amount of sulfur dioxide residue may not be positively correlated with the quality of sulfur-fumigated MC. Therefore, sulfur dioxide residue index alone may not objectively reflect the sulfur-fumigation extent (quality change extent) of MC, more specific method using characteristic sulfur-containing derivatives as chemical markers should be developed to supplement the sulfur dioxide residue determination in the quality control of sulfur-fumigated MC.
