Identification of chemical constituents in Yangxue Qingnao granule by UPLC-Q-TOF/MSE
10.16438/j.0513-4870.2015-0769
- VernacularTitle:UPLC-Q-TOF/MSE方法分析养血清脑颗粒的化学成分
- Author:
Dai-lin YANG
1
;
Ling TONG
2
;
Xiao-wen LI
2
;
Dong-xiang LI
2
;
Wen-yuan LIU
1
Author Information
1. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
2. State Key Laboratory of Core Technology in Innovative Chinese Medicine, Pharmaceutical Analysis Institute, Tasly Academy, Tianjin 300410, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Yangxue Qingnao granule;
UPLC-Q-TOF/MSE;
chemical profiling
- From:
Acta Pharmaceutica Sinica
2016;51(5):797-
- CountryChina
- Language:Chinese
-
Abstract:
In order to clarify the chemical constituents in Yangxue Qingnao granule, we established a rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry (UPLCQ- TOF/MSE) method. According to the high resolution MS spectra data, fragmentation ion information and retention time, 142 peaks were identified or tentatively presumed by comparison with reference standards data and literature reports. The herbal sources of these peaks were assigned. The results implied that phenolic acids, alkaloids, anthraquinones, phthalides, monoterpene glycosides were included in the main components of Yangxue Qingnao granule. The method is rapid for systematically elucidation of the constituents of Yangxue Qingnao granule and the results would facilitate the quality control of Yangxue Qingnao granule for safe and efficacious use.
