Construction of anti-CVB3 active molecule probe of matrinic derivatives

VernacularTitle:苦参酸类衍生物抗柯萨奇病毒B3的活性分子探针构建
Author: Sheng TANG ¹ ; Xin-yue CHENG ¹ ; Yu-huan LI ¹ ; Dan-qing SONG ¹ ; Ying-hong LI ¹
Author Information

1. Beijing Key Laboratory of Anti-infective Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Publication Type:ORIGINAL ARTICLES
Keywords: matrinic derivative; biotin; molecule probe; anti-CVB3 activity
From: Acta Pharmaceutica Sinica 2016;51(5):756-
CountryChina
Language:Chinese
Abstract: 12-N-Benzenesulfonyl-11-matrinic acid derivatives are a new class of anti-CVB3 compounds, but the mechanism of action is still unknown. Therein, two kinds of molecule probes were designed and constructed in this study, including matrinic amines that might be applied to the BIAcore fishing technique and biotin-tagged matrinic derivatives, which could be applied in the biotin affinity chromatography. Moreover, their anti-CVB3 activities were evaluated. Among them, 10a displayed a good activity with an IC₅₀ value of 0.8 μmol·L^-1. This active molecule probe provides a key chemical tool for exploration of the anti-CVB3 mechanism of this type of compounds.