Structure-activity relationship of gastrodin and parishins on learning and memory deficits induced by scopolamine
10.16438/j.0513-4870.2016-0196
- VernacularTitle:天麻素及派立辛改善东莨菪碱致学习记忆障碍的构效关系
- Author:
Zhi-hui LIU
1
;
Hao MA
1
;
Wei-ping WANG
1
;
Shao-feng XU
1
;
Ling WANG
1
;
Jian-gong SHI
1
;
Xiao-liang WANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
gastrodin;
parishin;
parishin C;
Morris water maze task;
long-term potentiation
- From:
Acta Pharmaceutica Sinica
2016;51(5):743-
- CountryChina
- Language:Chinese
-
Abstract:
Gastrodin, parishin and parishin C were purified from a water extract of GE (rhizome of Gastrodia elata, an herb medicine for treatment of neuronal disorders). In order to compare the pharmacological effects of gastrodin, parishin and parishin C on improving cognition deficits, we tested them in an animal model of cognition disorders induced by scopolamine and in a study of in vivo long-term potentiation (LTP) recordings. In the Morris water maze task, parishin C (15 and 50 mg·kg-1, P < 0.05) and parishin (150 mg·kg-1, P < 0.05), improved spatial learning and memory significantly. However, gastrodin showed no significant effects at the dose of 150 mg·kg-1. In vivo LTP recordings showed that parishin C at 5, 10 and 20 mg·kg-1, parishin at 10, 30 and 100 mg·kg-1 reversed the suppression of LTP by scopolamine in rats in a dose-dependent manner. However, gastrodin at 100 mg·kg-1 showed only a modest effect. In summary, the action of parishin C in the improvement of dementia induced by scopolamine was more potent than parishin and gastrodin.
