Advances of tumor targeting peptides drug delivery system with pH-sensitive activities
10.16438/j.0513-4870.2015-0838
- VernacularTitle:肿瘤靶向型pH敏感多肽类药物递送系统研究进展
- Author:
Yin-yun MA
1
;
Li LI
1
;
Hai-feng HUANG
1
;
San-hu GOU
1
;
Jing-man NI
1
Author Information
1. Pharmaceutics Institute, School of Pharmacy, Lanzhou University, Lanzhou 730000, China
- Publication Type:REVIEWS
- Keywords:
pH-sensitive;
peptide;
tumor targeting;
drug delivery system
- From:
Acta Pharmaceutica Sinica
2016;51(5):717-
- CountryChina
- Language:Chinese
-
Abstract:
The pH-sensitive peptides drug delivery systems, which target to acidic extracellular environment of tumor tissue, have many advantages in drug delivery. They exhibit a high specificity to tumor and low cytotoxicity, which significantly increase the efficacy of traditional anti-cancer drugs. In recent years the systems have received a great attention. The pH-sensitive peptides drug delivery systems can be divided into five types according to the difference in pH-responsive mechanism, type of peptides and carrier materials. This paper summarizes the recent progresses in the field with a focus on the five types of pH-sensitive peptides in drug delivery systems. This may provide a guideline to design and application of tumor targeting drugs.
