Advances in polymer-drug conjugated micelles in the delivery of anticancer drugs
10.16438/j.0513-4870.2015-0788
- VernacularTitle:聚合物药物结合物胶束在抗肿瘤药物递送方面的研究进展
- Author:
Xiao-lan YIN
1
;
Bo ZHANG
1
;
Yong-jun LIU
1
;
Na ZHANG
1
Author Information
1. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:REVIEWS
- Keywords:
polymer-drug conjugate;
micelle;
cancer therapy;
drug delivery
- From:
Acta Pharmaceutica Sinica
2016;51(5):710-
- CountryChina
- Language:Chinese
-
Abstract:
Polymer-drug conjugated micelles have many advantages as delivery vehicles of anticancer drugs. They can increase the solubility of hydrophobic drugs, extend the circulation time in vivo, improve the stability of anticancer drugs, reduce systemic toxicity and enhance the therapeutic effect of anticancer drugs, etc. moreover, a variety of polymers containing functional groups can also be used to prepare multi-functional polymer-drug conjugated micelles. In this article, polymer-drug conjugated micelles are reviewed and various multi-functional modification of polymer-drug conjugated micelles are introduced, and the recent progress of polymer-drug conjugated micelles in the delivery of anticancer drugs is summarized.
