Research progress of urotensin II and urotensin II receptor

VernacularTitle:尾加压素II及其受体的研究进展
Author: Rui ZHOU ¹ ; Li LI ¹ ; Xu LIU ² ; Guan-hua DU ¹
Author Information

1. Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Biomedical Engineering Research Center of Kunming Medical University, Kunming 650500, China
Publication Type:REVIEWS
Keywords: urotensin II; urotensin II receptor; urotensin II-related peptide; urotensin II receptor antagonist
From: Acta Pharmaceutica Sinica 2016;51(5):684-
CountryChina
Language:Chinese
Abstract: Urotensin II (UII) is the most potent vasoconstrictor among the identified vasoactive peptides. UII and its receptor (UT), which play varies of physiological roles, are widely expressed in central nerve system and peripheral organs. The change on the expressional level of UII/UT system has been proved to be closely correlated with pathological conditions. Therefore, UII/UT system was considered to be a potential target for treating many diseases. This review article is devoted to the latest research progress of UII/UT system in several aspects including ligand and receptor distribution, physiological activity, characteristics under pathological conditions and antagonist classification.