The relationship between catechol O-methyltransferase and diseases
10.16438/j.0513-4870.2015-0712
- VernacularTitle:儿茶酚氧位甲基转移酶与疾病的关系
- Author:
Xing-kai QIAN
1
;
Yang-liu XIA
1
;
Tong-yi DOU
1
;
Jie HOU
2
;
Hong MA
2
;
Guang-bo GE
1
;
Ling YANG
1
;
Xiao-lin BI
2
Author Information
1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
2. Dalian Medical University, Dalian 116044, China
- Publication Type:REVIEWS
- Keywords:
catechol O-methyltransferase;
metabolism;
disease
- From:
Acta Pharmaceutica Sinica
2016;51(4):543-
- CountryChina
- Language:Chinese
-
Abstract:
Catechol O-methyltransferase (COMT), one of the endogenous phase II metabolizing enzymes, expressed by chromosome 22. COMT catalyzes the transfer of a methyl group from common methyl donor S-adenosyl-L-methionine (AdoMet or SAM) to one of the catechol hydroxyls. COMT participates in the metabolism of many catechols in vivo, e.g. dopamine, epinephrine, noradrenaline, estradiol. Furthermore COMT also plays important roles in the metabolism of xenobiotic catechols from food and drug. COMT play a critical role in the management of catechols. Metabolism disorders of COMT can cause many diseases or an increased risk of diseases, e.g. Pakinson diseases, schizophrenia, and breast cancer. In this review, we explains the relationship of COMT and related-diseases through expounding disease caused by the COMT metabolic disorders. Finally, we hope that there will be more effective treatments for the COMT metabolism related diseases.
