Activatable cell-penetrating peptides: a potential activatable modality for diseases diagnosis and therapy
10.16438/j.0513-4870.2015-0656
- VernacularTitle:可激活的细胞穿透肽:一种应用于疾病诊断和治疗的极具潜力的可活化模式
- Author:
Shao-kun YANG
1
;
Xiao YAN
1
;
Wei-hong SUN
1
;
Qing DU
1
;
Bai XIANG
1
;
De-ying CAO
1
;
Xian-rong QI
2
Author Information
1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
2. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
- Publication Type:REVIEWS
- Keywords:
activatable cell-penetrating peptide;
tumor;
delivery system
- From:
Acta Pharmaceutica Sinica
2016;51(4):529-
- CountryChina
- Language:Chinese
-
Abstract:
Cell-penetrating peptides are composed of positively-charged amino acids that can mediate molecules or nano-carriers across cell membranes. However, most of the known cell-penetrating peptides have no cell-or tissue-specificity, with affinity to almost all types of cells in internalization. The non-specificity of cell-penetrating peptides is a significant obstacle in the application to targeted delivery of imaging probes and therapeutic agents. Accordingly, many studies focused on selective switching of systemically-delivered inert cell-penetrating peptides into active forms in diseased tissues. Tsien groups introduced the concept of activatable cell-penetrating peptides in 2004. Subsequently, a growing number of similar delivery systems (molecular or nano-sized) have been documented, and the sensitive factors have included enzyme, lower pH, light and exogenous component. In this paper, we make an overview of the development of activatable delivery system in recent years.
