Rules and characteristics of crystallization inhibition of cellulose polymers against drugs in supersaturated states
10.16438/j.0513-4870.2015-0664
- VernacularTitle:纤维素类聚合物抑制超饱和状态下药物结晶的规律特征
- Author:
Nian-qiu SHI
1
;
Yong ZHANG
2
;
Xiu-rong ZHANG
1
;
Bo FENG
1
;
Zheng-qiang LI
2
;
Xian-rong QI
3
Author Information
1. Jilin Medical University, Jilin 132013, China
2. Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Science, Jilin University, Changchun 130012, China
3. School of Pharmaceutical Science, Peking University, Beijing 100191, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
cellulose polymer;
supersaturated state;
amorphous;
crystallization inhibition
- From:
Acta Pharmaceutica Sinica
2016;51(3):462-
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to explore the characteristics of crystallization inhibition by cellulose polymers at the supersaturated states of drugs. The study was performed by simulating supersaturated process and preparing supersaturated drug solid, and was carried out by measuring the content of drugs at different time points using dissolution apparatus. The types, amounts, ionic intensity and viscosity of cellulose polymers were examined to assess the crystallization inhibition effect on BCS II class drug indomethacin. HPMC E15 exhibited the strongest crystallization inhibition effect. The more added, more obvious crystallization suppression was observed against indomethacin. The decrease in viscosity and increase in ionic intensity led to an enhanced inhibition. The research provides a scientific guide for the crystallization inhibition of supersaturated drug by cellulose polymers.
