Synthesis and antitumor activity of cinnamoyloxy phosphonate derivatives
10.16438/j.0513-4870.2015-0810
- VernacularTitle:肉桂酰氧基膦酸酯衍生物的合成与抗肿瘤活性
- Author:
Jia-qiang YANG
1
;
Jing LEI
1
;
Gang LI
1
;
Xiao-qiang WAN
1
Author Information
1. School of Pharmacy, Zunyi Medical College, Zunyi 563003, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
cinnamic acid;
α-hydroxyphosphonate;
microwave irradiation;
antitumor activity
- From:
Acta Pharmaceutica Sinica
2016;51(3):420-
- CountryChina
- Language:Chinese
-
Abstract:
In search of more effective anticancer agents, twelve compounds were designed and synthesized via microwave-assisted reactions of cinnamoyl chloride with α-hydroxyphosphonate. The structures of all the compounds were confirmed by IR, NMR and elemental analysis. Bioassay of the compounds were tested. They exhibited certain antitumor activities. Especially, compound 3c had obvious inhibitory effect on growth of SGC-7901 cells in vitro at 20 μmol·L-1, and compound 3h showed better inhibitory effect on growth of SGC-7901 cells in vitro at 5 μmol·L-1, the inhibition ratio were 68.8% and 48.0%, respectively.
