Technetium-99m-MIBI SPECT in Intracranial Lesions.
- Author:
Sung Chan PARK
1
;
Yong Kil HONG
;
Woo Hyun SUNG
;
Kyung Jin LEE
;
Young Sup PARK
;
Min Woo BAIK
;
Joon Ki KANG
;
Chang Rak CHOI
Author Information
1. Department of Neurosurgery, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Thallium;
99m Tc-MIBI SPECT;
Brain tumor
- MeSH:
Abscess;
Astrocytoma;
Brain;
Brain Neoplasms;
Craniopharyngioma;
Cysticercosis;
Ependymoma;
Gliosis;
Granuloma;
Hemangioblastoma;
Humans;
Infarction;
Meningioma;
Necrosis;
Radioactivity;
Thallium;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of Korean Neurosurgical Society
1994;23(5):548-552
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thallium(T1) has recently been used as a pharmaceutical for tumor imaging and staging. The aim of this study was to evaluate the clinical significance of the T1 analogue, 99m-Tc-MIBI(methoxyisobutylisonitrile), for imaging of intracranial lesions. The advantages of MIBI were though to be a lower radiation exposure and better image quality than with T1. 99m-Tc-MIBI SPECT studies were done in 30 patients with brain tumors(14 astrocytomas, 7 meningiomas, 2 hemangioblastomas, 2 craniopharyngiomas, 1 ependymoma, 4 metastatic tumors) and in twelve patients with non-tumorous lesions(2 abscesses, 2 granulomas, 2 cysticercosis, 3 old intracerebral hemorrages, 1 infarction. 1 postoperative gliosis, 1 unknown pathology), and semiquantitative assessment of tracer uptake was made using a ratio of radioactivity for lesion to contralateral normal brain(Lesion/Contralateral normal brains ; L/C). Twenty six of thirty tumors showed high L/C ratios(>1.5) and another four tumors low L/C ratios(<1.5). Of 12 non-tumorous intracranial lesions, 11 showed little or no uptake, but one moderate uptake. In conclusion, it appears that brain tumors show more intense focal uptake than non-tumorous brain lesions. However, further studies would be warranted to evaluate the clinical significance of MIBI SPECT in tumor staging(grading) and in differentiating necrosis from tumor regrowth more clearly.
