Research progress in medicines on protease-activated receptor 2
10.16438/j.0513-4870.2015-0523
- VernacularTitle:以蛋白酶活化受体2为靶点的药物研究进展
- Author:
Chao LI
1
;
Jin-hong HU
1
Author Information
1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
- Publication Type:REVIEWS
- Keywords:
protease-activated receptor 2;
agonist;
antagonist;
pepducin
- From:
Acta Pharmaceutica Sinica
2016;51(3):362-
- CountryChina
- Language:Chinese
-
Abstract:
Protease-activated receptor 2 (PAR2) is a member of protease-activated receptors (PARs). PAR2 distributed in tissues and cells (such as skin, airway epithelial cell, pancreas, etc.) has a broad biological effects, and is involved in pathogenesis of many diseases, such as mechanical pain, asthma, pain of pancreatic cancer, inflammation, pruritus, etc. Intervention of PAR2 will help us to identify the role of PAR2 in the mechanisms of diseases and in the development of new drugs. This article concentrates on the research progress of agonist, antagonist, and pepducin on PAR2.
