Advances in study of Survivin inhibitors
10.16438/j.0513-4870.2015-0579
- VernacularTitle:Survivin抑制剂研究进展
- Author:
Yan-qiu MENG
1
;
Li-wei LIU
1
;
Dong-ying LIU
1
;
Yan-ling SONG
1
Author Information
1. Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 100142, China
- Publication Type:REVIEWS
- Keywords:
Survivin inhibitor;
anti-tumor;
mechanism of action;
research progress
- From:
Acta Pharmaceutica Sinica
2016;51(3):347-
- CountryChina
- Language:Chinese
-
Abstract:
Survivin, a member of the inhibitor of apoptosis proteins family, is considered to be an important target of anticancer treatment for its key role in the control of cell division and cell apoptosis. Currently, only a few Survivin inhibitors have been developed, and most of them reduce Survivin level by interacting with other biomolecules instead of directly interacting with Survivin protein. This review summarizes the structure of Survivin protein, the mechanism of action and research progress of Survivin inhibitors, which may has a great significance in the study of selective Survivin inhibitors in the future.
