Hormesis of drugs for infectious diseases
10.16438/j.0513-4870.2015-0229
- VernacularTitle:抗感染药物的毒物兴奋效应浅析
- Author:
Miao YU
1
;
Ying GUO
1
Author Information
1. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
hormesis;
biphasic dose response;
infectious disease drug
- From:
Acta Pharmaceutica Sinica
2016;51(3):332-
- CountryChina
- Language:Chinese
-
Abstract:
Hormesis, a biphasic dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition, is a common feature of medicines but neglected sometime. Understanding of hormesis is essential for drug discovery and clinical application. Assessing hormetic range needs a proper experiment design including the number of doses and dose spacing, especially in the low dose zone. This article provides the shapes of hormetic dose-response curves, underlying mechanisms and the significance of hormesis for drugs of infectious diseases to facilitate drugs development and clinical applications.
