Construction and anti-tumor efficacy of a pentameric peptide vaccine that targets S100A8
10.16438/j.0513-4870.2015-0969
- VernacularTitle:一种靶向S100A8的五聚体重组多肽疫苗的构建及其抗肿瘤活性研究
- Author:
Ling-chong QIU
1
;
Wu-guang LU
1
;
Rong-xiu LI
1
Author Information
1. State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
immune escape;
S100A8;
cholera toxin B;
protein vaccine;
myeloid-derived suppressor cell
- From:
Acta Pharmaceutica Sinica
2016;51(2):294-
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSC) play critical roles in immune escape of tumor. We hypothesized that elimination of tumor-induced MDSCs might help to block tumor growth. Therefore, we constructed a cholera toxin B based peptide vaccine that targets a MDSC surface marker S100A8. Immunized BALB/c mice with CTB-S100A8 plus aluminum hydroxide induced high titers of anti-S100A8 antibodies and reduced tumor burden significantly in 4T1 mice model. We also found the vaccination led to significant reduction of tumor-induced monocytic MDSC (M-MDSC), with no effect on innate MDSCs, dendritic cell (DC) and macrophage (Mφ), demonstrating that targeting tumor-induced MDSC may be a promising approach in cancer immunotherapy.
