Establishment and application of a drug screening model for anti-prostate cancer agents targeting androgen receptor
10.16438/j.0513-4870.2015-0594
- VernacularTitle:以雄激素受体为靶标的抗前列腺癌药物筛选模型的建立和应用
- Author:
Yang HE
1
;
Yang-guang LIU
1
;
Ji-wei DING
1
;
Xiao-yu LI
1
;
Shan CEN
1
;
Jin-ming ZHOU
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
androgen receptor;
anti-prostate cancer;
reporter system;
traditional Chinese herb;
tripterygium wilfordii root extract;
drug screening
- From:
Acta Pharmaceutica Sinica
2016;51(2):287-
- CountryChina
- Language:Chinese
-
Abstract:
Androgen receptor (AR) plays an important role in the maintenance of prostate function and development of prostate cancer. AR is the key target in the therapy of prostate cancer. In this study, a cell-based screening assay was established by dual-luciferase reporter system to analyze the activity of AR. In the screening assay, we detected the anti-prostate cancer activities of rhodiola root extract, wild kiwifruit root extract and tripterygium wilfordii root extract, which may provide a new strategy for the treatment of prostate cancer.
