The development of cell-penetrating peptides in drug delivery system
10.16438/j.0513-4870.2015-0990
- VernacularTitle:细胞穿膜肽在药物递送系统中的研究进展
- Author:
Bo FAN
1
;
Ming-ji JIN
1
;
Wei HUANG
1
;
Qi-ming WANG
1
;
Zhong-gao GAO
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines/Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
cell-penetrating peptide;
drug delivery system;
nanoparticle
- From:
Acta Pharmaceutica Sinica
2016;51(2):264-
- CountryChina
- Language:Chinese
-
Abstract:
Cell membrane serves as the natural barrier. Cell-penetrating peptides (CPPs) have been a powerful vehicle for the intracellular delivery of a large variety of cargoes cross the cell membrane. The efficiency of intracellular delivery of drugs, proteins, peptides and nucleic acid, as well as various nanoparticu-late pharmaceutical carriers (e.g., liposomes, polymeric micelles and inorganic nanoparticles) has been demon-strated both in vitro and in vivo. This review focuses on the CPPs-based strategy for intracellular delivery of small molecule drugs, proteins, peptides, nucleic acid and CPP-modified nanocarriers.
