Research progress on anti-cancer mechanisms of arsenic trioxide and artemisinin
10.16438/j.0513-4870.2015-0996
- VernacularTitle:三氧化二砷和青蒿素抗肿瘤的机制研究进展
- Author:
Qing-xi YUE
1
;
Hong YU
2
;
Ting HE
3
;
Hai-qing YU
4
Author Information
1. Shanghai 3rd People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China
2. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia 65212, USA
3. Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
4. Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia 65212, USA
- Publication Type:REVIEWS
- Keywords:
arsenic trioxide;
artemisinin;
anti-cancer;
molecular mechanism
- From:
Acta Pharmaceutica Sinica
2016;51(2):208-
- CountryChina
- Language:Chinese
-
Abstract:
The formation and metastasis of tumor cells are closely related to the gene regulation. It is critical to elucidate the molecular mechanism of a compound using in cancer therapy. In this article, we reviewed the anti-cancer molecular mechanism of arsenic trioxide and artemisinin. Its anti-cancer function mainly includes:regulation of ① cell cycle regulatory proteins to inhibit tumor cell proliferation, ② cell apoptosis signal transduction pathway to promote apoptosis in tumor cells, ③ immortalization associated genes to reduce the life of tumor cells, ④ angiogenesis/invasion/metastasis gene to block the spread of tumor cells, ⑤ promoter methylation and protein ubiquitination gene to enhance anti-oncogene expression and ubiquitin-mediated protein degradation, ⑥ microRNA to inhibit proliferation or induce apoptosis in tumor cells, ⑦ DNA synthesis and repair of DNA damage and repair gene to decrease the DNA synthesis of tumor cells, ⑧ signal transduction pathways of cell proliferation/apoptosis and invasion/metastasis etc., ⑨ the expression of hor-mone receptors and so on. We indicated the problems existing in current studies and also prospected the future of using the compound to fight cancer.
