Biological characteristics of drug induced tumor cells and its medicine prevention and treatment
10.16438/j.0513-4870.2015-0985
- VernacularTitle:药物诱导型肿瘤细胞的生物学特性及药物防治
- Author:
Meng LI
1
;
Chun-fu WU
1
;
Jing-yuan ZHANG
1
;
Jing-yu YANG
1
;
Li-hui WANG
1
Author Information
1. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
- Publication Type:REVIEWS
- Keywords:
neoplastic stem cell;
recurrence;
drug resistance
- From:
Acta Pharmaceutica Sinica
2016;51(2):182-
- CountryChina
- Language:Chinese
-
Abstract:
Recently, the incidence and mortality of cancer has raised. More and more cytotoxic drugs and molecular targeted medicines have been used in clinic. However, most drugs just display a short-term anti-tumor effect. If patients received treatment for a long time, it would arise resistance to chemotherapy frequently. One of its important reasons is the accumulation of drug induced cancer cells. Thus, this paper emphasizes on biological character of drug induced cells, including cell biological phenotype, the change of gene and protein, variation of metabolism, dynamic change of signal transduction pathway and so on. Meanwhile, according to the characteristics of drug induced cells, we propose some strategies to inhibit drug induced cells, which would provide the foundation of clinical therapy and novel anti-tumor drug research and development.
