Relationship between hepatitis B virus X protein and hepatic cellular cancer
10.16438/j.0513-4870.2015-0570
- VernacularTitle:乙肝病毒X蛋白与肝癌的关系
- Author:
Ping-ping CAI
1
;
Jian-wei HUANG
2
;
Cheng-hao SU
2
;
Xiu-ling CUI
1
;
Rui-an XU
1
Author Information
1. Key Laboratory of Marine and Genetic Engineering Drugs, College of Biomedical Science, Institutes of Molecular Medicine, Huaqiao University, Xiamen 361021, China
2. Xiamen Municipal Center for Disease Control and Prevention, College of Biomedical Science, Institutes of Molecular Medicine, Huaqiao University, Xiamen 361021, China
- Publication Type:REVIEWS
- Keywords:
hepatitis B virus;
hepatitis B virus X protein;
hepatocarcinogenesis;
hepatic cellular cancer;
molecular mechanism
- From:
Acta Pharmaceutica Sinica
2016;51(2):165-
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic cellular cancer (HCC) is one of the most common cancers in the world, which is a serious threat to human health and life quality. More than 700 000 people die of HCC each year on average, and its incidence increases in many countries. Chronic hepatitis B virus (HBV) infection has been identified as a dominant risk factor for HCC. The pathogenesis of HBV-induced hepatocarcinogenesis is, however, incom-pletely understood. Evidence currently available supports a key role of the HBV X protein (HBx) in the cancer transformation and malignant tumor metastasis. HBx is a multifunctional regulator that may cooperate with the host factors to exert its effects on transcription, signal transduction, cell cycle progression, apoptosis, protein degradation, expression of oncogene and anti-oncogene. This review presents the current knowledge in the molecular pathogenesis of HBx in the induction of HCC.
