Identification of 3-demethylchuangxinmycin from <i>Actinoplanes tsinanensis</i> CPCC 200056

Li-jie Zuo; Wei Zhao; Zhi-bo Jiang; Bing-ya Jiang; Shu-fen LI; Hong-yu Liu; Li-yan YU; Bin Hong; Xin-xin HU; Xue-fu You; Lin-zhuan WU

Return

Identification of 3-demethylchuangxinmycin from Actinoplanes tsinanensis CPCC 200056

VernacularTitle:济南游动放线菌CPCC 200056产生的3-去甲创新霉素发现与鉴定
Author: Li-jie ZUO ¹ ; Wei ZHAO ¹ ; Zhi-bo JIANG ¹ ; Bing-ya JIANG ¹ ; Shu-fen LI ¹ ; Hong-yu LIU ¹ ; Li-yan YU ¹ ; Bin HONG ¹ ; Xin-xin HU ¹ ; Xue-fu YOU ¹ ; Lin-zhuan WU ¹
Author Information

1. Key Laboratory of Biotechnology of Antibiotics of National Health and Family Planning Commission, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Publication Type:ORIGINAL ARTICLES
Keywords: demethylchuangxinmycin; chuangxinmycin; Actinoplanes tsinanensis CPCC 200056
From: Acta Pharmaceutica Sinica 2016;51(1):105-
CountryChina
Language:Chinese
Abstract: Chuangxinmycin (CM) from Actinoplanes tsinanensis was an antibiotic discovered by Chinese scientists about 40 years ago. It contains a new heterocyclic system of indole fused with dihydrothiopyran, whose biosynthetic mechanism remains unclear. CM is used as an oral medicine in the treatment of bacterial infections in China. The simple structure makes CM as an attractive candidate of structure modification for improvement of antibacterial activity. Recently, we analyzed the secondary metabolites of Actinoplanes tsinanensis CPCC 200056, a CM producing strain, as a natural CM analogue. We discovered the first natural CM analogue 3-demethylchuangxinmycin (DCM) as a new natural product. Compared to CM, DCM exhibited a much weaker activity in the inhibition of the bacterial strains tested. The finding provides valuable information for the structure-activity relationship in the biosynthesis of CM.