Urinary metabolomics study of the effects of Scutellaria baicalensis Georgi ethanol extract on D-galactose-induced rats
10.16438/j.0513-4870.2015-0597
- VernacularTitle:黄芩醇提物干预D-半乳糖致衰老大鼠的尿液代谢组学研究
- Author:
Yan-fen CHANG
1
;
Wen-xia GONG
1
;
Yan-hong ZHENG
1
;
Jian-wei LI
1
;
Yu-zhi ZHOU
1
;
Xue-mei QIN
1
;
Guan-hua DU
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Scutellaria baicalensis;
anti-aging;
behavior research;
metabolomics
- From:
Acta Pharmaceutica Sinica
2016;51(1):86-
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study is to evaluate the anti-aging effects and reveal the underlying mechanism of Scutellaria baicalensis Georgi ethanol extract (SBG) in D-galactose-induced rats. Fifty rats were randomly divided into five groups: vehicle control group, D-galactose group, and D-galactose combined with 50, 100, 200 mg·kg-1 SBG. A rat aging model was induced by injecting subcutaneously D-galactose (100 mg·kg-1) for ten weeks. At the tenth week, the locomotor activity (in open-field test) and the learning and memory abilities (in Morris water maze test) were examined respectively. The urine was collected using metabolic cages and analyzed by high-resolution 1H NMR spectroscopy combined with multivariate statistical analyses. The SBG at doses of 50, 100 and 200 mg·kg-1 treatments groups could significantly ameliorate aging process in rats' cognitive performance. The 50, 100, 200 mg·kg-1 SBG regulated citrate, pyruvate, lactate, trimethylamine (TMA), pantothenate, β-hydroxybutyrate in urine favorably toward the control group. These biochemical changes are related to the disturbance in energy metabolism, glycometabolism and microbiome metabolism, which is helpful to further understanding the D-galactose induced aging rats and the therapeutic mechanism of SBG.
