Study on the regulation of autophagy against anticancer drugs' toxicity
10.16438/j.0513-4870.2015-0994
- VernacularTitle:自噬对抗肿瘤药物毒性的调控作用研究进展
- Author:
Xiao-e LOU
1
;
Yi ZHU
1
;
Qiao-jun HE
1
Author Information
1. Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
- Publication Type:SPECIAL REPORTS
- Keywords:
autophagy;
antineoplastic;
cardiotoxicity;
hepatoxicity;
neurontoxicity
- From:
Acta Pharmaceutica Sinica
2016;51(1):29-
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a crucial biological process in eukaryotes, which is involved in cell growth, survival and energy metabolism. It has been confirmed that autophagy mediates toxicity of anticancer drugs, especially in heart, liver and neuron. It is important to understand the function and mechanism of autophagy in anticancer drugs-induced toxicity. Given that autophagy is a double-edged sword in the maintenance of the function of heart, liver and neuron, the autophagy-mediated toxicity are very complicated in the body. We provide a review on the concept of autophagy and current status about autophagy-mediated toxicity of anticancer drugs. The knowledge is crucial in the basic study of anticancer drugs-induced toxicity, and provides some strategies for the development of alleviating the toxicity of anticancer drugs.
